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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHX
All Species:
17.58
Human Site:
T274
Identified Species:
27.62
UniProt:
O00330
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00330
NP_001128496.1
501
54122
T274
G
Q
P
N
A
V
G
T
F
T
E
I
P
A
S
Chimpanzee
Pan troglodytes
XP_001149489
501
54051
T274
G
Q
P
N
A
V
G
T
F
T
E
I
P
A
S
Rhesus Macaque
Macaca mulatta
XP_001109997
446
48686
A243
S
K
S
T
V
P
H
A
Y
A
T
A
D
C
D
Dog
Lupus familis
XP_533153
501
54075
T274
G
Q
P
N
V
P
G
T
F
T
E
I
P
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BKZ9
501
53981
T274
G
Q
P
N
A
A
G
T
F
T
E
I
P
A
S
Rat
Rattus norvegicus
P08461
632
67147
V404
V
A
P
T
P
A
G
V
F
I
D
I
P
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026358
502
53201
T273
G
Q
P
A
A
P
G
T
F
T
E
I
P
A
S
Frog
Xenopus laevis
NP_001087423
478
50485
R259
E
I
P
A
S
N
I
R
K
V
I
A
K
R
L
Zebra Danio
Brachydanio rerio
NP_956854
490
51982
E267
A
A
P
G
T
F
T
E
I
P
A
S
S
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624025
598
64649
V373
S
T
Y
Q
D
I
P
V
S
N
I
R
S
I
I
Nematode Worm
Caenorhab. elegans
Q19749
507
53448
T286
P
L
S
N
M
R
K
T
I
A
K
R
L
T
E
Sea Urchin
Strong. purpuratus
XP_001177721
482
51019
M261
S
Y
K
Q
T
E
G
M
F
S
E
V
D
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q0WQF7
637
68844
K371
V
A
A
I
A
S
G
K
A
S
K
S
S
A
S
Baker's Yeast
Sacchar. cerevisiae
P12695
482
51800
G264
S
T
M
R
S
I
I
G
E
R
L
L
Q
S
T
Red Bread Mold
Neurospora crassa
P20285
458
48601
V255
T
E
N
P
H
F
F
V
S
T
N
L
S
V
S
Conservation
Percent
Protein Identity:
100
99.5
87
90.2
N.A.
85.2
34.4
N.A.
N.A.
72.1
58.8
58
N.A.
N.A.
36.4
37.2
47.3
Protein Similarity:
100
99.8
87.6
93.2
N.A.
91.4
49.6
N.A.
N.A.
82
73.4
73
N.A.
N.A.
51.6
56.7
63
P-Site Identity:
100
100
0
86.6
N.A.
93.3
40
N.A.
N.A.
86.6
6.6
6.6
N.A.
N.A.
0
13.3
20
P-Site Similarity:
100
100
13.3
86.6
N.A.
93.3
46.6
N.A.
N.A.
86.6
13.3
6.6
N.A.
N.A.
6.6
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.9
32.7
34.7
Protein Similarity:
N.A.
N.A.
N.A.
48.9
51.9
51.1
P-Site Identity:
N.A.
N.A.
N.A.
26.6
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
20
7
14
34
14
0
7
7
14
7
14
0
40
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
7
0
14
0
7
% D
% Glu:
7
7
0
0
0
7
0
7
7
0
40
0
0
0
7
% E
% Phe:
0
0
0
0
0
14
7
0
47
0
0
0
0
0
0
% F
% Gly:
34
0
0
7
0
0
54
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
7
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
0
14
14
0
14
7
14
40
0
14
7
% I
% Lys:
0
7
7
0
0
0
7
7
7
0
14
0
7
0
0
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
7
14
7
7
7
% L
% Met:
0
0
7
0
7
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
34
0
7
0
0
0
7
7
0
0
0
0
% N
% Pro:
7
0
54
7
7
20
7
0
0
7
0
0
40
0
0
% P
% Gln:
0
34
0
14
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
7
0
7
0
7
0
7
0
14
0
7
7
% R
% Ser:
27
0
14
0
14
7
0
0
14
14
0
14
27
7
54
% S
% Thr:
7
14
0
14
14
0
7
40
0
40
7
0
0
7
14
% T
% Val:
14
0
0
0
14
14
0
20
0
7
0
7
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _